刺猬信号通路：Costal-2填补转导间隙。
Hedgehog signaling: Costal-2 bridges the transduction gap.
作者信息
Kalderon Daniel
机构信息
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
出版信息
Curr Biol. 2004 Jan 20;14(2):R67-9. doi: 10.1016/j.cub.2003.12.047.
PMID:14738752
Abstract
Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.
摘要
果蝇遗传学为刺猬信号通路提供了大致有序的组成部分，但机械连接很少。现在有几项研究表明，驱动蛋白相关蛋白Costal-2在跨膜转导器Smoothened和转录效应器Cubitus interruptus之间提供了物理连接。
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