Kalderon Daniel
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Curr Biol. 2004 Jan 20;14(2):R67-9. doi: 10.1016/j.cub.2003.12.047.
Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.
果蝇遗传学为刺猬信号通路提供了大致有序的组成部分，但机械连接很少。现在有几项研究表明，驱动蛋白相关蛋白Costal-2在跨膜转导器Smoothened和转录效应器Cubitus interruptus之间提供了物理连接。
