致病细菌的黏附素和侵袭素：结构视角

Adhesins and invasins of pathogenic bacteria: a structural view.

作者信息

Niemann Hartmut H, Schubert Wolf Dieter, Heinz Dirk W

机构信息

Department of Structural Biology, German Research Center for Biotechnology (GBF), Mascheroder Weg 1, 38124, Braunschweig, Germany.

出版信息

Microbes Infect. 2004 Jan;6(1):101-12. doi: 10.1016/j.micinf.2003.11.001.

DOI:10.1016/j.micinf.2003.11.001

PMID:14738899

Abstract

Adhesion and invasion of pathogenic bacteria represent the important initial step of infection. Pathogens utilize surface-located adhesins/invasins for specific interaction with host cell receptors. The three-dimensional structures of a number of adhesins/invasins show that many are elongated molecules containing domains commonly found in eukaryotic proteins. Similar folds are employed repeatedly to target different receptors.

摘要

致病细菌的黏附与侵袭是感染的重要起始步骤。病原体利用位于表面的黏附素/侵袭素与宿主细胞受体进行特异性相互作用。许多黏附素/侵袭素的三维结构表明，它们中的许多是细长分子，含有真核蛋白中常见的结构域。相似的折叠结构被反复用于靶向不同的受体。