Malecki Natacha, Carato Pascal, Rigo Benoît, Goossens Jean-François, Houssin Raymond, Bailly Christian, Hénichart Jean-Pierre
Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
Bioorg Med Chem. 2004 Feb 1;12(3):641-7. doi: 10.1016/j.bmc.2003.10.014.
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.
在新型稠合喹啉和喹唑啉中，其设计灵感来源于喜树碱和巴马司他等抗癌DNA结合生物碱，DNA结合试验确定8-甲氧基-7-哌嗪基丙氧基茚并[1,2-b]喹啉-11-酮四环体系是一种新的DNA识别基序。
