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苯基苯并咪唑和苯并咪唑并[1,2-c]喹唑啉的合成及其对DNA的亲和力

Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines.

作者信息

Lyakhova Elena A, Gusyeva Yulia A, Nekhoroshkova Julia V, Shafran Lev M, Lyakhov Sergey A

机构信息

AV Bogatsky Physico-Chemical Institute of NAS of Ukraine, Odessa, Ukraine.

出版信息

Eur J Med Chem. 2009 Aug;44(8):3305-12. doi: 10.1016/j.ejmech.2009.03.004. Epub 2009 Mar 21.

DOI:10.1016/j.ejmech.2009.03.004
PMID:19349097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7115644/
Abstract

Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K(a) values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.

摘要

新型N-(苯并咪唑基苯基)二烷基氨基烷基酰胺和6-二烷基氨基烷基苯并咪唑并[1,2-c]喹唑啉被制备为潜在的干扰素诱导剂和抗病毒剂。通过溴化乙锭置换试验对它们的DNA亲和力进行了筛选。结果表明，含有四环苯并咪唑并[1,2-c]喹唑啉片段的化合物的lg K(a)值比相应的无环苯基苯并咪唑衍生物大约高一个数量级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/e337778264d1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/133636c359a6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/ee7c5dcbb3b1/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/0f555d66ddb3/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/678beb591470/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/eb40e180ca97/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/4576b0b1afb7/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/e337778264d1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/133636c359a6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/ee7c5dcbb3b1/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/0f555d66ddb3/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/678beb591470/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/eb40e180ca97/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/4576b0b1afb7/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8114/7115644/e337778264d1/gr1.jpg

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