Jacques P F
USDA Human Nutrition Research Center on Aging, Department of Community Health, School of Medicine, Tufts University.
Int J Vitam Nutr Res. 1992;62(3):252-5.
Data collected as part of a study designed to examine the nutritional status of non-institutionalized elderly individuals, ages 60-100 years, residing in the Boston area were used to investigate the relationship between blood pressure (BP) and vitamin C intake reported by three-day diet records. Four hundred and ten subjects not taking antihypertensive medications were grouped into 5 categories of vitamin C intake: < 60, 60-119, 120-179, 180-239, > or = 240 mg/day. Relative differences in systolic and diastolic BP between subjects consuming > or = 240 mg/day compared to those consuming < 60 mg/day were -6.9% (p < 0.05) and -6.6% (p < 0.05), respectively. The prevalence of elevated BP (systolic > or = 160 mmHg or diastolic > or = 100 mmHg) was approximately 50% lower (p < 0.05) across this range of vitamin C intake. Adjustment of these associations for age, sex, body mass, smoking, dietary sodium:potassium ratio, and other dietary factors did little to alter the relationship between vitamin C and BP. These results lend support to the hypothesis that vitamin C and BP are related, but further research is required to test whether the relationship is causal.
作为一项旨在研究居住在波士顿地区、年龄在60至100岁之间的非机构化老年人营养状况的研究的一部分所收集的数据，被用于调查通过三日饮食记录报告的血压（BP）与维生素C摄入量之间的关系。410名未服用抗高血压药物的受试者被分为5类维生素C摄入量：<60、60 - 119、120 - 179、180 - 239、≥240毫克/天。与摄入<60毫克/天的受试者相比，摄入≥240毫克/天的受试者收缩压和舒张压的相对差异分别为-6.9%（p<0.05）和-6.6%（p<0.05）。在这个维生素C摄入量范围内，血压升高（收缩压≥160毫米汞柱或舒张压≥100毫米汞柱）的患病率大约低50%（p<0.05）。对这些关联进行年龄、性别、体重、吸烟、饮食中钠钾比和其他饮食因素的调整，对改变维生素C与血压之间的关系作用不大。这些结果支持了维生素C与血压相关的假设，但需要进一步研究来检验这种关系是否具有因果性。
