Dings Ruud P M, Nesmelova Irina, Griffioen Arjan W, Mayo Kevin H
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota, USA.
Angiogenesis. 2003;6(2):83-91. doi: 10.1023/B:AGEN.0000011730.94233.06.
Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controlling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.
癌症是一种因血管生成过多而引发的疾病。干扰这一过程为控制异常肿瘤生长提供了一种颇具吸引力的方法，这一假说最早于20世纪70年代初提出，引发了全球对识别和开发血管生成抑制剂的关注，目前这类抑制剂已有数百种。本文综述了抗血管生成蛋白片段和肽的发现与开发，重点在于理解它们的结构-功能关系，以助力设计出更优的治疗药物。
