Thiel S
Institute of Medical Microbiology, Aarhus University, Denmark.
Immunopharmacology. 1992 Sep-Oct;24(2):91-9. doi: 10.1016/0162-3109(92)90015-5.
Mannan-binding protein is an animal serum lectin (i.e. a molecule with the ability to bind specifically to certain carbohydrate structures). The relevant carbohydrate ligands are found on many pathogenic microorganisms. After binding to suitable carbohydrate ligands, mannan-binding protein is found to be an activator of the classical pathway of complement via an activation of the C1r2C1s2 complex, i.e. antibody and C1q independent. The molecular organization of MBP resembles that of C1q with a distinct division of collagen-like and globular amino acid sequences. This molecular similarity seems to be the basis for the common functional activity of the two proteins. MBP may play an important protective role, especially at early stages of infection prior to the generation of the specific humoral and cellular defence system. The paper explores the structure and the physiological functions of mannan-binding protein.
甘露聚糖结合蛋白是一种动物血清凝集素（即一种能够特异性结合某些碳水化合物结构的分子）。许多致病微生物上都存在相关的碳水化合物配体。在与合适的碳水化合物配体结合后，甘露聚糖结合蛋白通过激活C1r2C1s2复合物被发现是补体经典途径的激活剂，即不依赖抗体和C1q。甘露聚糖结合蛋白（MBP）的分子结构类似于C1q，具有明显的胶原样和球状氨基酸序列划分。这种分子相似性似乎是这两种蛋白质共同功能活性的基础。MBP可能发挥重要的保护作用，尤其是在特异性体液和细胞防御系统产生之前的感染早期。本文探讨了甘露聚糖结合蛋白的结构和生理功能。
