Buchanan Benjamin R, Andrews Frank M
Department of Large Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville 37996, USA.
Vet Clin North Am Equine Pract. 2003 Dec;19(3):575-97. doi: 10.1016/j.cveq.2003.08.012.
EGUS is a common problem in horses and foals. Acids are the important causative factors and current therapy targets the suppression of gastric HCl and creation of a permissive environment for ulcer healing. Diagnosis is based on history, clinical signs, gastroscopy, and response to treatment. Of the products available, only GastroGard (FDA approved) and ranitidine have been shown to be efficacious in the treatment of EGUS. Ranitidine is often associated with treatment failure as a result of incorrect dosing and lack of owner compliance, because of the three times daily dosing required. Also, EGUS occurs in critically ill neonatal foals, but the pathogenesis may be different than in adult horses and acid-suppressive therapy may not be as effective.
内镜检查阴性的胃溃疡（EGUS）是马和马驹常见的问题。酸是重要的致病因素，目前的治疗目标是抑制胃内盐酸分泌并为溃疡愈合创造适宜的环境。诊断基于病史、临床症状、胃镜检查及对治疗的反应。在现有产品中，只有胃溃安（GastroGard，已获美国食品药品监督管理局批准）和雷尼替丁已被证明对治疗EGUS有效。由于给药剂量不正确以及主人依从性差（因为需要每日给药三次），雷尼替丁治疗常出现失败情况。此外，EGUS也发生于危重新生马驹，但发病机制可能与成年马不同，抑酸治疗可能效果不佳。
