Andrews F M, Sifferman R L, Bernard W, Hughes F E, Holste J E, Daurio C P, Alva R, Cox J L
College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
Equine Vet J Suppl. 1999 Apr(29):81-6. doi: 10.1111/j.2042-3306.1999.tb05176.x.
Equine gastric ulcer syndrome (EGUS) is very common among performance horses, with a reported prevalence of approximately 90% in racehorses, and also > 50% in foals. Omeprazole, an acid pump inhibitor 5 times more potent than ranitidine, has been used with great success to treat EGUS. This multicentre study of Thoroughbred racehorses with endoscopically verified gastric ulcers was designed to demonstrate the efficacy of an equine oral paste formulation of omeprazole in the treatment and prevention of recurrence of EGUS. Of the 100 horses entered into the study, 25 were sham-dosed for the full 58 days of the study. The remaining 75 horses all received omeprazole paste, 4 mg/kg bwt/day once daily for 28 days. At Day 28, 25 of treated horses continued on this dosing regimen while 25 received a half dose (2 mg/kg bwt once daily) and 25 horses were sham-dosed. By Day 28, gastric ulcers were completely healed in 77% of omeprazole-treated horses, while 92% were significantly (P < 0.01) improved. In contrast, 96% of the sham-dosed horses still had gastric ulcers at Day 28. The improvement was maintained in horses that continued on either a full dose or half dose of omeprazole paste until Day 58. However, in those horses that were removed from omeprazole treatment at Day 28, the incidence and severity of the gastric ulcers at the end of the study were similar to those horses that did not receive the omeprazole paste. This study demonstrates that omeprazole paste, 4 mg/kg bwt per os, once daily, is highly effective in healing gastric ulcers in Thoroughbred racehorses and that either a full dose or half dose of omeprazole paste effectively prevents the recurrence of EGUS. The study also indicates that gastric ulcers in untreated horses did not demonstrate a significant rate of spontaneous healing.
马胃溃疡综合征（EGUS）在役用马中非常常见，据报道，赛马的患病率约为90%，驹的患病率也超过50%。奥美拉唑是一种比雷尼替丁效力强5倍的酸泵抑制剂，已成功用于治疗EGUS。这项针对经内镜证实患有胃溃疡的纯种赛马的多中心研究旨在证明奥美拉唑马用口服糊剂在治疗和预防EGUS复发方面的疗效。在参与该研究的100匹马中，25匹在研究的整整58天内接受假给药。其余75匹马均接受奥美拉唑糊剂，剂量为4mg/kg体重/天，每天一次，持续28天。在第28天，25匹接受治疗的马继续按此给药方案用药，25匹接受半剂量（2mg/kg体重，每天一次），25匹马接受假给药。到第28天，77%接受奥美拉唑治疗的马胃溃疡完全愈合，而92%有显著改善（P<0.01）。相比之下，在第28天，96%接受假给药的马仍患有胃溃疡。继续接受全剂量或半剂量奥美拉唑糊剂治疗的马，其改善情况一直维持到第58天。然而，在第28天停止奥美拉唑治疗的那些马中，研究结束时胃溃疡的发生率和严重程度与未接受奥美拉唑糊剂的马相似。这项研究表明，口服4mg/kg体重的奥美拉唑糊剂，每天一次，在治愈纯种赛马胃溃疡方面非常有效，全剂量或半剂量的奥美拉唑糊剂都能有效预防EGUS的复发。该研究还表明，未治疗的马胃溃疡未显示出显著的自发愈合率。
