Cooke Graham S, Aucan Christophe, Walley Andrew J, Segal Shelley, Greenwood Brian M, Kwiatkowski Dominic P, Hill Adrian V S
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Am J Trop Med Hyg. 2003 Dec;69(6):565-8.
Malaria continues to claim the lives of more children worldwide than any other infectious disease, and improved understanding of disease immunology is a priority for the development of new therapeutic and vaccination strategies. FcgammaRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated with variability in susceptibility to both bacterial diseases and Plasmodium falciparum parasitemia. We investigated the role of this polymorphism in West Africans with mild and severe malarial disease. The HH131 genotype was significantly associated with susceptibility to severe malaria (P = 0.03, odds ratio = 1.40, 95% confidence interval = 1.02-1.91). In contrast to studies of parasitemia, the presence of the R131 allele, rather than the RR131 genotype, appeared to be the important factor in protection from disease. This is the first evidence for an association between CD32 polymorphism and severe malaria and provides an example of balancing selective pressures from different infectious diseases operating at the same genetic locus.
在全球范围内，疟疾导致死亡的儿童数量仍高于其他任何传染病，因此深入了解疾病免疫学是开发新治疗方法和疫苗接种策略的首要任务。FcγRIIa（CD32）包含一种多态性变体（H/R131），该变体与细菌疾病易感性和恶性疟原虫血症的变异性有关。我们研究了这种多态性在患有轻度和重度疟疾的西非人中的作用。HH131基因型与严重疟疾易感性显著相关（P = 0.03，比值比 = 1.40，95%置信区间 = 1.02 - 1.91）。与疟原虫血症研究不同，R131等位基因的存在而非RR131基因型似乎是预防疾病的重要因素。这是CD32多态性与严重疟疾之间存在关联的首个证据，并提供了一个在同一基因位点平衡来自不同传染病的选择性压力的例子。
