严重疟疾性贫血和脑型疟疾与不同的肿瘤坏死因子启动子等位基因相关。

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.

作者信息

McGuire W, Knight J C, Hill A V, Allsopp C E, Greenwood B M, Kwiatkowski D

机构信息

Department of Paediatrics, John Radcliffe Hospital, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom.

出版信息

J Infect Dis. 1999 Jan;179(1):287-90. doi: 10.1086/314533.

DOI:10.1086/314533

PMID:9841857

Abstract

Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the same population, severe malarial anemia was associated with the TNF-238 A allele, with an odds ratio of 2.5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene.

摘要

实验证据表明肿瘤坏死因子（TNF）与疟疾贫血的发病机制有关，但与此假设相关的数据很少。本研究发现，与脑型疟疾患者血浆中高水平的TNF不同，严重贫血的恶性疟原虫感染儿童血浆TNF水平较低。此前在冈比亚进行的一项病例对照研究发现，脑型疟疾而非严重疟疾贫血与TNF - 308 A等位基因有关。本研究发现，在同一人群中，严重疟疾贫血与TNF - 238 A等位基因有关，在按HLA类型分层后，优势比为2.5（P <.001）。这些发现表明，严重疟疾贫血和脑型疟疾受TNF基因附近不同遗传因素的影响。