用于可控药物递送的集成微系统。

Integrated microsystems for controlled drug delivery.

作者信息

Razzacki S Zafar, Thwar Prasanna K, Yang Ming, Ugaz Victor M, Burns Mark A

机构信息

Department of Chemical Engineering, University of Michigan, 2300 Hayward, 3074 HH Dow Building, Ann Arbor, MI 48109-2136, USA.

出版信息

Adv Drug Deliv Rev. 2004 Feb 10;56(2):185-98. doi: 10.1016/j.addr.2003.08.012.

DOI:10.1016/j.addr.2003.08.012

PMID:14741115

Abstract

Efficient drug delivery and administration are needed to realize the full potential of molecular therapeutics. Integrated microsystems that incorporate extremely fast sensory and actuation capabilities can fulfill this need for efficient drug delivery tools. Photolithographic technologies borrowed from the semiconductor industry enable mass production of such microsystems. Rapid prototyping allows for the quick development of customized devices that would accommodate for diverse therapeutic requirements. This paper reviews the capabilities of existing microfabrication and their applications in controlled drug delivery microsystems. The next generation of drug delivery systems--fully integrated and self-regulating--would not only improve drug administration, but also revolutionize the health-care industry.

摘要

为了充分发挥分子疗法的潜力，需要高效的药物递送和给药方式。集成了极快速传感和驱动能力的微系统能够满足对高效药物递送工具的这一需求。借鉴半导体行业的光刻技术可实现此类微系统的大规模生产。快速原型制作能够快速开发出可满足各种治疗需求的定制设备。本文综述了现有微加工技术的能力及其在可控药物递送微系统中的应用。下一代药物递送系统——完全集成且自我调节——不仅会改善药物给药方式，还将给医疗保健行业带来变革。