Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.

作者信息

Sawada Masae, Washizuka Ken ichi, Okumura Hiroyuki

机构信息

Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co Ltd, 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan.

出版信息

Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. doi: 10.1016/j.bmcl.2003.11.072.

DOI:10.1016/j.bmcl.2003.11.072

PMID:14741258

Abstract

The synthesis and biological properties of a novel squalene epoxidase inhibitor, FR194738, are described. This compound displayed potent in vitro inhibitory activities against squalene epoxidase and cholesterol synthesis, and lowered plasma cholesterol and triglyceride levels in dogs.

摘要