苄胺的磺胺衍生物在HepG2细胞中阻断胆固醇生物合成：一种新型强效角鲨烯环氧酶抑制剂。
Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.
作者信息
Gotteland J P, Loubat C, Planty B, Junquéro D, Delhon A, Halazy S
机构信息
Medicinal Chemistry Division, Centre de Recherche Pierre Fabre, Castres, France.
出版信息
Bioorg Med Chem Lett. 1998 Jun 2;8(11):1337-42. doi: 10.1016/s0960-894x(98)00213-3.
PMID:9871762
Abstract
Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as cholesterol biosynthesis inhibitors.
摘要
烯炔苄胺1的磺胺衍生物已被制备出来，并被鉴定为一类新型的强效SE抑制剂，已在HepG2细胞中作为胆固醇生物合成抑制剂表现出活性。
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