Lugovaia E A, Gorbachev A L, Efimova A V
International Scientific Center Arktika, Fareastern Branch Russian Academy of Sciences, Magadan, 685000.
Adv Gerontol. 2003;12:103-10.
On the base of macro- and microelements' concentration in hair of Magadan's inhabitants there were analyzed the changes of aged people's element status. It has been shown that with age, differently directed reconstruction happened, leading to accumulation of one elements and decrease of concentration of others in inhabitants' hair. Elements, undergoing natural age reconstruction, may be considered as indicators and initiators of aging. We have allocated two groups of elements, in dependence on changes' direction. The first group is the main one; Na, K, Ca, Se, As, Mg, Mn, Fe, Zn belong to this group; their level in hair is increasing with age. Taking into account the excretory function of hair, accumulation of named elements is considered as aged removing of these elements out of organism. The exception is the toxic As: its superfluous concentrations in hair reflect the accumulation As in the internal environment of organism. Elements (Cr, Si), concentration of which in hair is decreasing with age, belong to the second group. On the base of literary data, the decreasing of named elements in hair must be interpreted as their programmed decreasing in the organism of aged people. Hence, in aged people there is seen the generalized decreasing of the most studied essential macro- and microelements in the organism. The exception is As, concentration of which is increasing in aged people. The age disorder of element homeostasis may serve as a predictor of "normal" diseases and may be one of pathophysiological mechanisms of aging.
基于马加丹居民头发中常量和微量元素的浓度，分析了老年人元素状态的变化。结果表明，随着年龄的增长，发生了不同方向的重构，导致居民头发中一种元素的积累和其他元素浓度的降低。经历自然年龄重构的元素可被视为衰老的指标和引发因素。根据变化方向，我们划分了两组元素。第一组是主要的；钠、钾、钙、硒、砷、镁、锰、铁、锌属于这一组；它们在头发中的水平随着年龄的增长而增加。考虑到头发的排泄功能，这些元素的积累被认为是这些元素从生物体中随年龄排出。例外的是有毒的砷：其在头发中的过量浓度反映了砷在生物体内环境中的积累。头发中浓度随年龄降低的元素（铬、硅）属于第二组。根据文献数据，头发中这些元素的减少必须解释为它们在老年人机体中的程序性减少。因此，在老年人中可以看到机体中大多数已研究的必需常量和微量元素普遍减少。例外的是砷，其在老年人中的浓度在增加。元素稳态的年龄紊乱可能是“正常”疾病的预测指标，并且可能是衰老的病理生理机制之一。
