Wang Cheng-shuo, Dong Zhen
Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130031, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.
To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of nasal mucosa.
Specimens from 30 patients with chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA.
All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005).
It is suggested that epithelial in nasal mucosa were not just a physical barrier, which could represent a novel defense mechanism of the host during bacterial infections through Toll-like receptors.
了解Toll样受体2（TLR-2）和Toll样受体4（TLR-4）在鼻黏膜上皮细胞中的表达情况，探讨Toll样受体在鼻黏膜固有免疫中的作用。
采用原位杂交法检测30例慢性鼻窦炎患者和21例健康成年人的TLR-2和TLR-4 mRNA。
30例慢性鼻窦炎样本中TLR-2和TLR-4的表达均高于对照组（t = 8.605，P < 0.0005；t = 9.050，P < 0.0005）。
提示鼻黏膜上皮不仅是一道物理屏障，在细菌感染期间可能通过Toll样受体代表宿主一种新的防御机制。
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