[Expression of inducible nitric oxide synthase mRNA in epithelial cell of nasal mucosa is upregulated through Toll-like receptor-4].

作者信息

Wang Chengshuo, Dong Zhen, Guan Guimei, Yang Zhanquan

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130031, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 May;18(5):268-9.

PMID:15311504

Abstract

OBJECTIVE

To investigate the upregulation of inducible nitric oxide synthase (iNOS) in epithelial cell of nasal mucosa through Toll-like receptor-4 (TLR-4).

METHOD

Specimens from 30 patients of chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-4 and iNOS mRNA.

RESULT

All 30 samples of chronic sinusitis showed a stronger expression of TLR-4 and iNOS than in controls (P<0.01). iNOS upregulated in nasal epithelium correlated with TLR-4 (r=0.435, P<0.01).

CONCLUSION

It suggested that TLR-4 may play a role in enhancing local host defence and inflammation via upregulating the expression of iNOS mRNA and the subsequent increased production of NO.

摘要