Durnev A D, Smol'nikova N M, Nemova E P, Val'dman E A, Avdiunina N I, Piatin B M, Seredenin S B
Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Eksp Klin Farmakol. 2003 Nov-Dec;66(6):32-5.
Himantane introduced via a gastric tube to pregnant rats in a dose of 10, 30, 50, and 100 mg/kg produced a dose-dependent embryotoxic and teratogenic action. An analysis of the experimental results and published data suggests that the embryotoxicity of himantane can be related to its general toxic action upon the organism of pregnant female rats.
通过胃管给怀孕大鼠分别注射剂量为10、30、50和100毫克/千克的金刚烷胺，会产生剂量依赖性的胚胎毒性和致畸作用。对实验结果和已发表数据的分析表明，金刚烷胺的胚胎毒性可能与其对怀孕雌性大鼠机体的一般毒性作用有关。
