Vreugdenhil Hestien J I, Mulder Paul G H, Emmen Harry H, Weisglas-Kuperus Nynke
Department of Pediatrics, Division of Neonatology, Erasmus MC--Sophia, Rotterdam, Netherlands.
Neuropsychology. 2004 Jan;18(1):185-93. doi: 10.1037/0894-4105.18.1.185.
PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB--dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982). A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL.
多氯联苯以其神经毒性特性而闻名，尤其是对发育中的大脑。为了更深入了解多氯联苯暴露的神经毒性作用，作者研究了围产期暴露于环境水平的这些化合物对不同神经心理领域的影响。在鹿特丹多氯联苯 - 二恶英队列研究中9岁儿童里，较高的产前多氯联苯水平与更长的反应时间、反应时间的更多变异性以及伦敦塔测试（TOL；Shallice，1982）的较低分数相关。更长的母乳喂养持续时间与较低的伦敦塔测试分数以及更好的空间组织技能相关。有一些证据表明哺乳期暴露于多氯联苯对伦敦塔测试分数有负面影响。
