Ramli Rahayu, Durand Daniel, Fried Nathaniel M
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
J Endourol. 2003 Dec;17(10):923-6. doi: 10.1089/089277903772036307.
Cooling methods are commonly used in dermatology to protect the skin surface during cosmetic laser procedures. This study investigated deep laser heating of tissue in combination with cryogen cooling of the surface for potential noninvasive targeting of subsurface tissue structures in urology.
Porcine liver and skin were studied because they represent simple and difficult tissue models, respectively, for subsurface lesion production. Gross and histologic methods were used to measure lesion dimensions.
Liver lesions measured 4.9 +/- 1.2 mm in diameter, while preserving the tissue surface to a depth of 2.1 +/- 0.4 mm (N = 5). Surface temperatures remained below 40 degrees C, while lesion temperatures ranged from 60 to 70 degrees C. Skin lesions measured 4.1 +/- 0.6 mm, while preserving the skin surface to a depth of 1.2 +/- 0.2 mm (N = 4).
This technique may prove useful to target subsurface anatomic structures in urology.
在美容激光手术中，冷却方法常用于保护皮肤表面。本研究探讨了组织深层激光加热联合表面冷冻剂冷却，用于泌尿外科潜在的非侵入性靶向皮下组织结构。
研究了猪肝和猪皮，因为它们分别代表了用于产生皮下病变的简单和困难组织模型。采用大体和组织学方法测量病变尺寸。
肝脏病变直径为4.9±1.2毫米，同时将组织表面保存至2.1±0.4毫米深度（N = 5）。表面温度保持在40摄氏度以下，而病变温度范围为60至70摄氏度。皮肤病变为4.1±0.6毫米，同时将皮肤表面保存至1.2±0.2毫米深度（N = 4）。
该技术可能对泌尿外科靶向皮下解剖结构有用。
