Danial Nika N, Korsmeyer Stanley J
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2004 Jan 23;116(2):205-19. doi: 10.1016/s0092-8674(04)00046-7.
Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
程序性细胞死亡是后生动物所必需的一种独特的遗传和生化途径。完整的死亡途径对于胚胎的成功发育和正常组织稳态的维持至关重要。事实证明，细胞凋亡与其他重要的细胞途径紧密相连。细胞死亡途径中关键控制点的确定为基础生物学提供了基本见解，也为新疗法提供了合理的靶点。
