Wang Zi-Bing, Liu Yu-Qing, Cui Yu-Fang
Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, 100850 Beijing, China.
Cell Biol Int. 2005 Jul;29(7):489-96. doi: 10.1016/j.cellbi.2005.04.001.
Apoptosis or programmed cell death is an active form of cell death which is essential for tissue homeostasis. Many proteins are involved in the molecular signal transduction of apoptosis. The caspase enzymes, a family of specific cysteine proteases, play a central role in cell death machinery. In this review, we mainly discuss the current understanding of several pathways to activate caspases and some key proteins related to these pathways.
细胞凋亡或程序性细胞死亡是一种对组织稳态至关重要的主动细胞死亡形式。许多蛋白质参与细胞凋亡的分子信号转导。半胱天冬酶（caspase）家族，一类特异性半胱氨酸蛋白酶，在细胞死亡机制中起核心作用。在本综述中，我们主要讨论目前对几种激活半胱天冬酶途径以及与这些途径相关的一些关键蛋白质的理解。
