Mori Tomohisa, Kawano Ken-Ichi, Shishikura Takashi
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
J Pharmacol Sci. 2004 Jan;94(1):73-6. doi: 10.1254/jphs.94.73.
The present study was designed to compare the effects of a selective 5-HT(3)-receptor antagonist, alosetron, on the glycerol-and colorectal distention (CRD)-induced visceral nociception as measured by changes in EMG of the external oblique muscle in conscious rats. Both glycerol and CRD evoked the EMG response, and these amplified EMG were attenuated by morphine, indicating that these responses might reflect visceral nociceptive responses. In the present study, we showed that alosetron significantly attenuated the glycerol-induced visceral pain, but not that of CRD. These results suggest that the mechanism of glycerol-induced visceral nociception are apparently different from that of CRD.
本研究旨在比较选择性5-羟色胺（5-HT）3受体拮抗剂阿洛司琼对甘油和结肠扩张（CRD）诱导的内脏伤害感受的影响，通过清醒大鼠腹外斜肌肌电图的变化来测量。甘油和CRD均诱发了肌电图反应，且这些放大的肌电图被吗啡减弱，表明这些反应可能反映了内脏伤害感受反应。在本研究中，我们发现阿洛司琼显著减轻了甘油诱导的内脏疼痛，但对CRD诱导的疼痛没有作用。这些结果表明，甘油诱导的内脏伤害感受机制与CRD明显不同。
