[兴奋性突触传递的分子机制：AMPA受体的动态调节]

[Molecular mechanisms of excitatory synaptic transmission: dynamic regulation of AMPA receptors].

作者信息

Kato Akihiko, Sugiyama Hiroyuki

机构信息

Department of Physiology, University of California, San Francisco 94107, USA.

出版信息

Nihon Yakurigaku Zasshi. 2004 Feb;123(2):113-22. doi: 10.1254/fpj.123.113.

DOI:10.1254/fpj.123.113

PMID:14745131

Abstract

AMPA receptors play central roles for synaptic transmission in the central nervous system in mammals. Here we review the molecular mechanisms for how AMPA receptor subunits are correctly assembled, how AMPA receptors are conveyed to dendrites, and how AMPA receptors are exposed in postsynaptic sites. We also discuss the molecular mechanisms of synaptic plasticity that is the cellular basis of learning and memory.

摘要

AMPA 受体在哺乳动物中枢神经系统的突触传递中发挥着核心作用。在此，我们综述了 AMPA 受体亚基如何正确组装、AMPA 受体如何被转运至树突以及 AMPA 受体如何在突触后位点暴露的分子机制。我们还讨论了作为学习和记忆细胞基础的突触可塑性的分子机制。