Katsumata Shin-Ichi, Masuyama Ritsuko, Koshihara Moyuru, Matsuzaki Hiroshi, Uehara Mariko, Suzuki Kazuharu
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
Biosci Biotechnol Biochem. 2004 Jan;68(1):243-6. doi: 10.1271/bbb.68.243.
In this study, we ascertained whether the parathyroid hormone (PTH) dominantly regulated the effects of high phosphorus (P) intakes on urinary excretion of P and bone metabolism in rats. To maintain serum PTH level equally, parathyroidectomy (PTX) and sham-operated rats were constantly exposed to rPTH(1-34) and fed both control (0.3% P) and high P (1.2% P) diet for 7 days, respectively. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. These results suggest that high P diet increased urinary P excretion while promoting bone resorption regardless of PTH-dependent regulation.
