Katsumata Shin-ichi, Matsuzaki Hiroshi, Uehara Mariko, Suzuki Kazuharu
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Biosci Biotechnol Biochem. 2006 Feb;70(2):528-31. doi: 10.1271/bbb.70.528.
We investigated whether lowering food intake by high phosphorus (P) diet influenced parathyroid hormone (PTH) actions, bone turnover markers, and kidney mineral concentration in rats. Rats in two of the three groups were respectively given free access to a control diet (C group) and a high P diet (HP group) for 21 days. Rats in another group (PF group) were pair-fed the control diet with the HP group. Compared to the C and PF groups, serum PTH concentration, urinary C-terminal telopeptide of type I collagen excretion, and kidney calcium and P concentrations were significantly higher in the HP group. Urinary excretion of cAMP was significantly lower in the HP group than in the C and PF groups. These results suggested that high P diet decreased PTH action in the kidney and increased bone resorption and kidney mineral concentrations independently of lowering food intake.
我们研究了高磷（P）饮食降低食物摄入量是否会影响大鼠甲状旁腺激素（PTH）的作用、骨转换标志物和肾脏矿物质浓度。三组中的两组大鼠分别自由进食对照饮食（C组）和高磷饮食（HP组）21天。另一组（PF组）大鼠与HP组配对喂食对照饮食。与C组和PF组相比，HP组血清PTH浓度、尿I型胶原C末端肽排泄量以及肾脏钙和磷浓度显著更高。HP组cAMP的尿排泄量显著低于C组和PF组。这些结果表明，高磷饮食可降低肾脏中PTH的作用，并独立于食物摄入量的降低而增加骨吸收和肾脏矿物质浓度。
