Song Il Han
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
Korean J Gastroenterol. 2004 Jan;43(1):1-7.
Cancer metastasis, a complex and sequential network of cellular events involved in the migration and establishment of malignant cells from original site to distant foci, is an important and significant contributor to morbidity and mortality of cancer patients. Despite the clinical importance of cancer metastasis, its molecular and biochemical mechanism remains unclear. The identification of tumor suppressor gene confirmed that metastasis might involve the functional loss of genes that maintain the cellular differentiation optimally. Metastasis suppressor is defined by the ability to reduce the metastatic property of cancer cells without affecting its tumorigenesis. Since NM23 was first identified in 1988 as a metastasis suppressor, several metastasis suppressor genes have been identified and characterized. In this article, we review the complex and multi-step process of cancer metastasis and describe the recent progress of metastasis suppressors in the studies of identified. Consequently, we hope to introduce the new therapeutic target for the metastasis suppressors in cancer patients.
癌症转移是一个复杂且有序的细胞事件网络，涉及恶性细胞从原发部位迁移至远处病灶并在那里定植，是导致癌症患者发病和死亡的一个重要因素。尽管癌症转移在临床上具有重要意义，但其分子和生化机制仍不清楚。肿瘤抑制基因的鉴定证实，转移可能涉及那些能最佳维持细胞分化的基因功能丧失。转移抑制因子的定义是能够降低癌细胞的转移特性而不影响其肿瘤发生能力。自1988年首次鉴定出NM23作为一种转移抑制因子以来，已鉴定并表征了多个转移抑制基因。在本文中，我们综述了癌症转移这一复杂的多步骤过程，并描述了已鉴定的转移抑制因子研究的最新进展。因此，我们希望能为癌症患者引入针对转移抑制因子的新治疗靶点。
