维生素C带来的希望、幻灭与更多希望。
Hopes, disillusions and more hopes from vitamin C.
作者信息
De Tullio M C, Arrigoni O
机构信息
Dipartimento di Biologia e Patologia Vegetale, Università di Bari, Via E. Orabona 4, 70125 Bari, Italy.
出版信息
Cell Mol Life Sci. 2004 Jan;61(2):209-19. doi: 10.1007/s00018-003-3203-8.
Abstract
In the current view of most biochemists and physiologists, the role of L-ascorbic acid (AA) in cell metabolism would be more or less confined to the scavenging of reactive oxygen species. Nevertheless, many data have been collected in our and other laboratories concerning the involvement of AA in many different aspects of cell metabolism. At the present time the molecular sites of action of AA have not been completely elucidated, but recent findings on the specific requirement of AA for the activity of several 2-oxoacid-dependent dioxygenases involved in cell signalling and the activation of transcription factors open new fascinating perspectives for further research.
摘要
在大多数生物化学家和生理学家目前的观点中，L-抗坏血酸（AA）在细胞代谢中的作用或多或少局限于清除活性氧。然而，我们实验室和其他实验室已经收集了许多关于AA参与细胞代谢许多不同方面的数据。目前，AA的分子作用位点尚未完全阐明，但最近关于AA对参与细胞信号传导和转录因子激活的几种2-氧代酸依赖性双加氧酶活性的特定需求的发现为进一步研究开辟了新的迷人前景。
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