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[使用可卡因或甲哌卡因进行结膜下麻醉用于晚期青光眼的睫状体冷凝术]

[Subconjunctival anaesthesia using cocaine or mepivacaine for cyclocryotherapy in advanced glaucoma].

作者信息

Mielke Jörg, Schlote Torsten

机构信息

Universitäts-Augenklinik Tübingen, Abteilung I: Erkrankungen des vorderen und hinteren Augenabschnitts, Tübingen.

出版信息

Klin Monbl Augenheilkd. 2004 Jan;221(1):24-8. doi: 10.1055/s-2003-812633.

Abstract

BACKGROUND

Retro- or peribulbar anaesthesia are the standard procedures for cyclodestructive surgery. Because these methods of anaesthesia may further compromise optic nerve function, especially in advanced glaucoma, subconjunctival anaesthesia was evaluated as an alternative procedure in cyclocryotherapy.

PATIENTS AND METHODS

  1. To evaluate the current methods of anaesthesia a questionnaire was sent to all University Eye Clinics in Germany in 2001. 2. A prospective, consecutive study concerning cyclocryotherapy in advanced glaucoma was started using subconjunctival anaesthesia with 5 % cocaine or, alternatively, 2 % mepivacaine in 25 eyes of 25 patients in each group. Pain during cyclocryotherapy was recorded using a 10-point rating-scale (1 = no pain to 10 = intolerably severe pain) and adverse events were also recorded.

RESULTS

  1. 88.6 % of the University Eye Clinics in Germany replied to our questionnaire. In 2001 cyclocryotherapy was performed in 80.6 % of the University Eye Clinics in Germany (Tübingen not included), 16.1 % among them solely used cyclocryotherapy for the treatment of advanced glaucoma. 2. Using 5 % cocaine for subconjunctival anaesthesia - 92 % of patients experienced no pain and 8 % of patients reported very mild pain during cyclocryotherapy. One patient reported nausea, 4 patients mouth dryness. After anaesthesia with mepivacaine - 80 % experienced no pain, 12 % very mild pain, and 8 % mild pain. There were no systemic side effects.

CONCLUSION

Most of the patients experienced no pain during cyclocryotherapy using subconjunctival anaesthesia with cocaine or mepivacaine. Therefore, risks and side effects of retro- or parabulbar anaesthesia can be successfully avoided by this simple modification.

摘要

背景

球后或球周麻醉是睫状体破坏手术的标准操作方法。由于这些麻醉方法可能会进一步损害视神经功能,尤其是在晚期青光眼患者中,因此评估了结膜下麻醉作为睫状体冷冻疗法的替代方法。

患者与方法

  1. 为评估当前的麻醉方法,2001年向德国所有大学眼科诊所发送了一份调查问卷。2. 开始了一项关于晚期青光眼睫状体冷冻疗法的前瞻性连续研究,每组25例患者的25只眼中,采用5%可卡因或2%甲哌卡因进行结膜下麻醉。使用10分制评分量表记录睫状体冷冻疗法期间的疼痛情况(1分 = 无疼痛至10分 = 难以忍受的剧痛),并记录不良事件。

结果

  1. 德国88.6%的大学眼科诊所回复了我们的调查问卷。2001年,德国80.6%的大学眼科诊所进行了睫状体冷冻疗法(不包括图宾根诊所),其中16.1%仅将睫状体冷冻疗法用于治疗晚期青光眼。2. 使用5%可卡因进行结膜下麻醉时,92%的患者在睫状体冷冻疗法期间无疼痛,8%的患者报告有非常轻微的疼痛。1例患者报告恶心,4例患者报告口干。使用甲哌卡因麻醉后,80%的患者无疼痛,12%的患者有非常轻微的疼痛,8%的患者有轻微疼痛。未出现全身副作用。

结论

大多数患者在使用可卡因或甲哌卡因进行结膜下麻醉的睫状体冷冻疗法期间无疼痛。因此,通过这种简单的改进,可以成功避免球后或球周麻醉的风险和副作用。

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