胎儿双侧肾缺如、短肢畸形及单脐动脉与孕早期可卡因滥用相关。
Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy.
作者信息
Kashiwagi Maki, Chaoui Rabih, Stallmach Thomas, Hürlimann Sandra, Lauper Urs, Hebisch Gundula
机构信息
Department of Obstetrics & Gynecology, Clinic of Obstetrics & Division of Perinatal, Physiology, University of Zurich, Zurich, Switzerland.
出版信息
Birth Defects Res A Clin Mol Teratol. 2003 Nov;67(11):951-2. doi: 10.1002/bdra.10101.
BACKGROUND
Maternal cocaine abuse in pregnancy is associated with complications such as intrauterine growth retardation, abruptio placentae, and preterm delivery.
CASE
We report what is, to our knowledge, the first published observation of fetal bilateral renal agenesis associated with a vascular disruption syndrome comprising upper limb reduction defect and a single umbilical artery following maternal cocaine abuse in early pregnancy.
CONCLUSIONS
This constellation in a fetus aborted at 18 weeks extends the spectrum of complications possibly associated with cocaine abuse in pregnancy.
背景
孕期母亲滥用可卡因与诸如胎儿宫内生长受限、胎盘早剥和早产等并发症相关。
病例
据我们所知，我们报告了首例关于胎儿双侧肾缺如的公开观察病例，该病例与一种血管破坏综合征有关，该综合征包括上肢发育不全缺陷和单脐动脉，其母亲在孕早期滥用可卡因。
结论
在18周流产胎儿中出现的这一症状群扩展了孕期可卡因滥用可能相关的并发症范围。
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