Bae Kyongtae T, McDermott Ronan, Gierada David S, Heiken Jay P, Nolte Mark A, Takahashi Naoki, Hong Cheng
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA.
Acad Radiol. 2004 Jan;11(1):61-8. doi: 10.1016/s1076-6332(03)00536-1.
The feasibility of using gadolinium contrast medium for computed tomography angiography (CTA) in multi-detector row computed tomography and the effect of contrast medium dilution was investigated.
Three pigs were each scanned in multiple sessions with injections of non-dilute and dilute contrast medium at a dose of 0.3 mmol/kg body weight. Non-spiral dynamic scanning at a fixed mid-abdominal aortic level and thoracoabdominal CTA were performed.
The magnitude of peak aortic enhancement was not significantly different between dilute and non-dilute contrast medium injections (P = .88), but the former showed earlier enhancement (mean of 2.3 seconds sooner, P < .01) than the latter. CT angiography with gadolinium contrast medium showed much lower enhancement than iodine contrast medium, but small vessels were readily identifiable.
Gadolinium contrast medium combined with multi-detector row computed tomography may provide clinically useful CTA. Dilution of contrast medium shortens the enhancement time but has little effect on the magnitude.
研究了在多排螺旋计算机断层扫描中使用钆对比剂进行计算机断层血管造影（CTA）的可行性以及对比剂稀释的效果。
对三只猪进行多次扫描，分别注射剂量为0.3 mmol/kg体重的未稀释和稀释对比剂。在固定的腹主动脉中部水平进行非螺旋动态扫描，并进行胸腹CTA。
稀释对比剂和未稀释对比剂注射后主动脉峰值强化程度无显著差异（P = 0.88），但前者比后者强化更早（平均早2.3秒，P < 0.01）。钆对比剂CT血管造影显示强化程度远低于碘对比剂，但小血管易于识别。
钆对比剂联合多排螺旋计算机断层扫描可能提供临床上有用的CTA。对比剂稀释可缩短强化时间，但对强化程度影响不大。
