Caddick Stephen, Wilden Jonathan D, Judd Duncan B
The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
J Am Chem Soc. 2004 Feb 4;126(4):1024-5. doi: 10.1021/ja0397658.
A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under heterogeneous conditions is also described. These methods provide a fundamentally new approach to making small molecules containing the sulfonamide functional group.
描述了一种通过使用三苯基膦二氟甲磺酸盐试剂使磺酸盐与胺和醇直接偶联来制备磺酰胺和活性磺酸酯的通用新方法。还描述了一种用于在非均相条件下进行这些转化的新型可重复使用的聚合物负载试剂。这些方法为制备含有磺酰胺官能团的小分子提供了一种全新的方法。
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