Chen Jinyang, Han Xiaoran, Mei Lan, Liu Jinchuan, Du Kui, Cao Tuanwu, Li Qiang
College of Chemistry and Chemical Engineering, Yangtze Normal University Fuling Chongqing 408000 P. R. China
Institution of Functional Organic Molecules and Materials, School of Chemistry and Chemical Engineering, Liaocheng University No. 1, Hunan Street Liaocheng Shandong 252059 P. R. China.
RSC Adv. 2019 Oct 2;9(54):31212-31216. doi: 10.1039/c9ra07361b. eCollection 2019 Oct 1.
This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides the sulfonylation of sulfonyl hydrazides with -amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and -butyl hydroperoxide was used as the oxidant.
本研究提供了一种直接、可持续且环保的方法来合成各种磺胺类化合物，即通过磺酰肼与胺的磺酰化反应。该方法利用磺酰肼通过选择性断裂C-N键来氧化并与叔胺偶联。在该反应中，使用分子碘作为催化剂，叔丁基过氧化氢作为氧化剂。
