碘催化磺酰肼与胺的磺酰化反应：一种绿色高效合成磺酰胺的方法。
Iodine-catalyzed sulfonylation of sulfonyl hydrazides with -amines: a green and efficient protocol for the synthesis of sulfonamides.
作者信息
Chen Jinyang, Han Xiaoran, Mei Lan, Liu Jinchuan, Du Kui, Cao Tuanwu, Li Qiang
机构信息
College of Chemistry and Chemical Engineering, Yangtze Normal University Fuling Chongqing 408000 P. R. China
Institution of Functional Organic Molecules and Materials, School of Chemistry and Chemical Engineering, Liaocheng University No. 1, Hunan Street Liaocheng Shandong 252059 P. R. China.
出版信息
RSC Adv. 2019 Oct 2;9(54):31212-31216. doi: 10.1039/c9ra07361b. eCollection 2019 Oct 1.
This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides the sulfonylation of sulfonyl hydrazides with -amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and -butyl hydroperoxide was used as the oxidant.
本研究提供了一种直接、可持续且环保的方法来合成各种磺胺类化合物，即通过磺酰肼与胺的磺酰化反应。该方法利用磺酰肼通过选择性断裂C-N键来氧化并与叔胺偶联。在该反应中，使用分子碘作为催化剂，叔丁基过氧化氢作为氧化剂。
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