具有磺酸酯和磺酰胺核苷酸间连接的非离子型寡核苷酸类似物的合成进展。
Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages.
作者信息
Secrist J A, Crooks P A, Maddry J A, Reynolds R C, Rathore A S, Ahktar M S, Montgomery J A
机构信息
Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255-5305.
出版信息
Nucleic Acids Symp Ser. 1991(24):5-8.
PMID:1841378
Abstract
The synthesis of building blocks for the preparation of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages is described. Coupling conditions for the conversion of several of these monomers to dimers are also described.
摘要
本文描述了用于制备具有磺酸酯和磺酰胺核苷酸间连接的非离子型寡核苷酸类似物的构建模块的合成方法。还描述了其中几种单体转化为二聚体的偶联条件。
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