Gothelf Kurt V, Thomsen Anne, Nielsen Morten, Cló Emiliano, Brown Raymond S
Center for Catalysis and Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, Langelandsgade 140, Aarhus University, 8000 Aarhus C, Denmark.
J Am Chem Soc. 2004 Feb 4;126(4):1044-6. doi: 10.1021/ja038333u.
A new strategy for self-assembly and covalent coupling of encoded molecular modules into nanostructures with predetermined connectivity has been developed. The method uses DNA-functionalized oligo(phenylene ethynylene)-derived organic modules for controlling the assembly and covalent coupling of multiple modules. Rigid linear modules (LM) and tripoidal modules (TM) were functionalized with short oligonucleotides at each terminus. They can hybridize and thereby link up modules containing complementary sequences. Each terminus of the oligo(phenylene ethynylene) modules also consists of a salicylaldehyde moiety, which can form metal-salen complexes with other modules. The salicylaldehyde groups of two modules are brought in proximity when their adjoining DNA sequences are complementary, and they selectively form a manganese-salen complex in the presence of ethylenediamine and manganese acetate. The resulting structures consist of a matrix of linear and branched oligo(phenylene ethynylene)s which are linked by conjugated and rigid manganese-salen complexes. These nanostructures are potential conductors for applications in molecular electronics.
一种将编码分子模块自组装并共价偶联成具有预定连接性的纳米结构的新策略已经被开发出来。该方法使用DNA功能化的亚苯基乙炔衍生有机模块来控制多个模块的组装和共价偶联。刚性线性模块（LM）和三脚架模块（TM）在每个末端都用短寡核苷酸进行了功能化。它们可以杂交，从而连接包含互补序列的模块。亚苯基乙炔模块的每个末端还包含一个水杨醛部分，其可以与其他模块形成金属-萨伦配合物。当两个模块相邻的DNA序列互补时，它们的水杨醛基团会靠近，并在乙二胺和乙酸锰存在的情况下选择性地形成锰-萨伦配合物。所得结构由线性和支化亚苯基乙炔的矩阵组成，这些亚苯基乙炔通过共轭和刚性的锰-萨伦配合物连接。这些纳米结构是分子电子学应用中的潜在导体。
