Wu Wenting, Shao Xiaodong, Zhao Jianzhang, Wu Mingbo
State Key Laboratory of Heavy Oil Processing China University of Petroleum Qingdao 266580 China.
State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116024 P. R. China.
Adv Sci (Weinh). 2017 Jun 23;4(7):1700113. doi: 10.1002/advs.201700113. eCollection 2017 Jul.
With singlet oxygen (O) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, HO and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e.g. captivity and release), are described as a key point in the article. This review provide a general overview of designing novel PS or strategies for effective and controllable PDT.
以单线态氧（O）作为活性剂，光动力疗法（PDT）是一种治疗各种肿瘤和癌症的很有前景的技术。但它受到大多数传统光敏剂（PS）选择性差的阻碍。在本综述中，我们总结了通过调节单线态氧效率实现的可控光动力疗法。在此，基于不同起始条件（如pH、光、HO等）的各种可控光动力疗法策略已被总结和介绍。更重要的是，可控光动力疗法策略的作用机制，如光诱导电子转移（PET）、荧光共振能量转移（FRET）、分子内电荷转移（ICT）以及一些物理/化学手段（如捕获和释放），在本文中被作为重点进行了描述。本综述提供了设计新型光敏剂或有效且可控光动力疗法策略的总体概述。
