Padial M A, Alvarez-Ferreira J, Tapia B, Blanco R, Mañas C, Blanca M, Bellón T
Department of Allergy, Hospital Universitario La Paz, P degrees Castellana 261, 28046 Madrid, Spain.
Br J Dermatol. 2004 Jan;150(1):139-42. doi: 10.1111/j.1365-2133.2004.05717.x.
Acute generalized exanthematous pustulosis (AGEP) is an uncommon skin disorder most often caused by drugs. Few adverse reactions to sympathomimetic drugs have been reported, despite their extensive use. Although the aetiology of AGEP remains uncertain, recent data have reported involvement of drug-specific T cells and interleukin (IL)-8 production. We characterized an adverse reaction to pseudoephedrine both clinically and immunologically. Histological analysis of skin biopsies confirmed the clinical entity as AGEP, while epicutaneous tests confirmed the specificity of the reaction to the drug. Moreover, immunohistochemical studies showed a mononuclear infiltrate consisting of activated memory T cells in addition to polymorphonuclear cells. Reverse transcription-polymerase chain reaction revealed an increased expression of IL-8 in AGEP-affected skin.
急性泛发性脓疱性皮病（AGEP）是一种罕见的皮肤疾病，最常见的病因是药物。尽管拟交感神经药被广泛使用，但对其不良反应的报道却很少。虽然AGEP的病因尚不确定，但最近的数据表明药物特异性T细胞和白细胞介素（IL）-8的产生与之有关。我们从临床和免疫学角度对伪麻黄碱的不良反应进行了特征描述。皮肤活检的组织学分析证实临床诊断为AGEP，而皮试证实了该反应对药物的特异性。此外，免疫组化研究显示除多形核细胞外，还有由活化记忆T细胞组成的单核浸润。逆转录-聚合酶链反应显示AGEP受累皮肤中IL-8表达增加。
