Yoshioka K, Yoshida T, Kondo M
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Jpn J Physiol. 1992;42(4):673-80. doi: 10.2170/jjphysiol.42.673.
A high fat (HF) diet is known to induce obesity, but susceptibility to obesity induced by a HF diet differs not only among different strains of rats but also within the same strain. The present study revealed that the Lee index (an index of obesity) positively correlated with insulin, and inversely correlated with both the mitochondrial oxygen consumption in interscapular brown adipose tissue (BAT) and the resting metabolic rate (RMR) in Sprague-Dawley rats. This suggests the contribution of BAT thermogenesis and RMR, in addition to hyperphagia, to the intrastrain variation in susceptibility to HF diet-induced obesity.
已知高脂（HF）饮食会诱发肥胖，但高脂饮食诱发肥胖的易感性不仅在不同品系的大鼠之间存在差异，在同一品系内也有所不同。本研究表明，在斯普拉格-道利大鼠中，李氏指数（一种肥胖指数）与胰岛素呈正相关，与肩胛间棕色脂肪组织（BAT）中的线粒体氧消耗和静息代谢率（RMR）均呈负相关。这表明，除了摄食过多外，BAT产热和RMR对品系内高脂饮食诱导肥胖易感性的个体差异也有影响。
