咖啡因可激活小鼠的棕色脂肪组织产热和代谢率。

Caffeine activates brown adipose tissue thermogenesis and metabolic rate in mice.

作者信息

Yoshioka K, Yoshida T, Kamanaru K, Hiraoka N, Kondo M

机构信息

First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1990 Apr;36(2):173-8. doi: 10.3177/jnsv.36.173.

DOI:10.3177/jnsv.36.173

PMID:2388099

Abstract

To clarify the effect of caffeine on brown adipose tissue (BAT) thermogenesis, we measured guanosine-5'-diphosphate (GDP) binding, a thermogenic indicator of BAT, and oxygen consumption in BAT mitochondria as well as BAT temperature and resting metabolic rate (RMR) in mice. Intraperitoneal injection of caffeine (60 mg/kg) significantly elevated BAT temperature with less effect on core temperature, and increased significantly GDP binding and oxygen consumption in BAT mitochondria, and RMR. These results suggest that caffeine activates BAT thermogenesis, which may contribute to the increase of RMR.

摘要

为阐明咖啡因对棕色脂肪组织（BAT）产热的影响，我们测量了小鼠BAT的产热指标——鸟苷-5'-二磷酸（GDP）结合量、BAT线粒体中的氧消耗量以及BAT温度和静息代谢率（RMR）。腹腔注射咖啡因（60毫克/千克）可显著提高BAT温度，而对核心体温影响较小，并显著增加BAT线粒体中的GDP结合量和氧消耗量以及RMR。这些结果表明，咖啡因可激活BAT产热，这可能有助于RMR的增加。