Mitchell Patrick, Gholkar Anil, Vindlacheruvu Raghu R, Mendelow A David
Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK.
Lancet Neurol. 2004 Feb;3(2):85-92. doi: 10.1016/s1474-4422(03)00661-6.
15 years ago, the treatment of incidentally discovered intracranial aneurysms was straightforward with a good evidence base behind it. When intracranial aneurysms were identified, people were referred to neurosurgeons who would offer surgical repair if the patient was in reasonable health and had a good life expectancy. Since that time, several studies have given contradictory evidence for what should be done with these lesions, and a new technique for the repair of aneurysms, endovascular coil embolisation, has been developed. Here we review the research and make several recommendations. First, incidentally discovered aneurysms in the anterior circulation less than 7 mm in size in people with no personal or family history of subarachnoid haemorrhage should be left untreated. Second, people with remaining life expectancy of less than 20 years or so (ie, those over age 60 years) should be informed that from a statistical point of view the benefits of treatment do not outweigh the risks. Third, in all other cases treatment with surgical clipping or coil embolisation should be advised. And finally, if surgical treatment is not feasible then medical hypotensive treatment may be a viable alternative.
15年前,偶然发现的颅内动脉瘤的治疗方法很简单,且有充分的证据支持。当颅内动脉瘤被发现时,患者会被转介给神经外科医生,如果患者身体健康且预期寿命较长,神经外科医生会进行手术修复。从那时起,几项研究对于这些病变该如何处理给出了相互矛盾的证据,并且一种用于修复动脉瘤的新技术——血管内线圈栓塞术——已经被开发出来。在此,我们回顾相关研究并给出一些建议。首先,对于没有蛛网膜下腔出血个人或家族史的人群,偶然发现的前循环中直径小于7毫米的动脉瘤应不予治疗。其次,预期剩余寿命不到20年左右的人群(即60岁以上的人群)应被告知,从统计学角度来看,治疗的益处并不大于风险。第三,在所有其他情况下,建议采用手术夹闭或线圈栓塞治疗。最后,如果手术治疗不可行,那么药物降压治疗可能是一种可行的替代方法。