Bates M, Everard J, Wall L, Horsman J M, Hancock B W
Trophoblastic Disease Centre, YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Whitham Road, Sheffield S10 2SJ, UK.
Hum Reprod. 2004 Feb;19(2):365-7. doi: 10.1093/humrep/deh068.
The aim of the study was to record the incidence of treatment for infertility prior to development of gestational trophoblastic disease (GTD).
A retrospective analysis was undertaken of 231 consecutive women receiving chemotherapy for persistent GTD at Weston Park Hospital, Sheffield, from 1991 to 2001. Three patients in this group had received treatment for infertility prior to their molar pregnancy. In a control group of 226 patients not requiring treatment for persistent GTD, four had had treatment for infertility just before their molar pregnancy, and in a further control group of 208 'normal' pregnancies, eight patients had had treatment for infertility prior to conception.
We conclude that we can demonstrate no relationship between infertility treatment and subsequent development of GTD.
本研究的目的是记录妊娠滋养细胞疾病（GTD）发生前的不孕症治疗发生率。
对1991年至2001年在谢菲尔德韦斯顿公园医院接受持续性GTD化疗的231例连续女性进行回顾性分析。该组中有3例患者在葡萄胎妊娠前接受过不孕症治疗。在226例不需要接受持续性GTD治疗的对照组患者中，有4例在葡萄胎妊娠前接受过不孕症治疗，在另外208例“正常”妊娠的对照组中，有8例患者在受孕前接受过不孕症治疗。
我们得出结论，不孕症治疗与随后发生的GTD之间不存在关联。
