Scott N, Millward E, Cartwright E J, Preston S R, Coletta P L
Department of Pathology, St James's University Hospital, United Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.
J Clin Pathol. 2004 Feb;57(2):189-92. doi: 10.1136/jcp.2003.10660.
To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours.
Twenty six carcinoid tumours from the stomach, small intestine, appendix, and colorectum were investigated by immunohistochemistry for GRP and GRPR.
GRP was detected in nine of 19 tumours and GRPR in 22 of 26. Coexpression of both the ligand and receptor was seen in six of 19 cases. GRPR but not GRP was more strongly expressed in appendix and colonic tumours.
GRP and GRPR are produced by a large number of gastrointestinal carcinoid tumours. An autocrine/paracrine pathway may exist for GRP stimulated cell proliferation in some of these neoplasms, analogous to that seen in small cell anaplastic carcinoma of the lung.
确定胃泌素释放肽（GRP）和胃泌素释放肽受体（GRPR）在胃肠道类癌肿瘤中是否共同表达。
采用免疫组织化学方法对来自胃、小肠、阑尾和结肠直肠的26例类癌肿瘤进行GRP和GRPR检测。
19例肿瘤中有9例检测到GRP，26例中有22例检测到GRPR。19例中有6例观察到配体和受体的共表达。GRPR在阑尾和结肠肿瘤中表达更强，而GRP则不然。
大量胃肠道类癌肿瘤可产生GRP和GRPR。在其中一些肿瘤中，GRP刺激细胞增殖可能存在自分泌/旁分泌途径，类似于肺小细胞间变性癌中所见。
