胃泌素释放肽及胃泌素释放肽受体在胃肠道类癌肿瘤中的表达
Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours.
作者信息
Scott N, Millward E, Cartwright E J, Preston S R, Coletta P L
机构信息
Department of Pathology, St James's University Hospital, United Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.
出版信息
J Clin Pathol. 2004 Feb;57(2):189-92. doi: 10.1136/jcp.2003.10660.
Abstract
AIMS
To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours.
METHODS
Twenty six carcinoid tumours from the stomach, small intestine, appendix, and colorectum were investigated by immunohistochemistry for GRP and GRPR.
RESULTS
GRP was detected in nine of 19 tumours and GRPR in 22 of 26. Coexpression of both the ligand and receptor was seen in six of 19 cases. GRPR but not GRP was more strongly expressed in appendix and colonic tumours.
CONCLUSIONS
GRP and GRPR are produced by a large number of gastrointestinal carcinoid tumours. An autocrine/paracrine pathway may exist for GRP stimulated cell proliferation in some of these neoplasms, analogous to that seen in small cell anaplastic carcinoma of the lung.
摘要
目的
确定胃泌素释放肽（GRP）和胃泌素释放肽受体（GRPR）在胃肠道类癌肿瘤中是否共同表达。
方法
采用免疫组织化学方法对来自胃、小肠、阑尾和结肠直肠的26例类癌肿瘤进行GRP和GRPR检测。
结果
19例肿瘤中有9例检测到GRP，26例中有22例检测到GRPR。19例中有6例观察到配体和受体的共表达。GRPR在阑尾和结肠肿瘤中表达更强，而GRP则不然。
结论
大量胃肠道类癌肿瘤可产生GRP和GRPR。在其中一些肿瘤中，GRP刺激细胞增殖可能存在自分泌/旁分泌途径，类似于肺小细胞间变性癌中所见。
相似文献
1
Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours.胃泌素释放肽及胃泌素释放肽受体在胃肠道类癌肿瘤中的表达
J Clin Pathol. 2004 Feb;57(2):189-92. doi: 10.1136/jcp.2003.10660.
2
Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans.人高分化结肠癌中胃泌素释放肽及其受体的异常表达。
Am J Physiol. 1999 Mar;276(3):G655-65. doi: 10.1152/ajpgi.1999.276.3.G655.
3
Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.胃泌素释放肽受体介导的头颈部鳞状细胞癌自分泌生长
J Natl Cancer Inst. 2002 Mar 6;94(5):375-83. doi: 10.1093/jnci/94.5.375.
4
Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice.胃泌素释放肽参与小鼠变应性鼻炎的形成。
Laryngoscope. 2018 Nov;128(11):E377-E384. doi: 10.1002/lary.27394. Epub 2018 Aug 27.
5
Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide.胃泌素释放肽受体对胃泌素释放肽选择性的分子基础。
Mol Pharmacol. 2002 Jun;61(6):1435-43. doi: 10.1124/mol.61.6.1435.
6
Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP).鉴定胃泌素释放肽受体（GRPR）中负责胃泌素释放肽（GRP）高亲和力结合的关键氨基酸。
Biochem Pharmacol. 2005 Feb 15;69(4):579-93. doi: 10.1016/j.bcp.2004.11.003. Epub 2004 Dec 23.
7
Expression of GRP and its receptor is associated with improved survival in patients with colon cancer.胃泌素释放肽（GRP）及其受体的表达与结肠癌患者生存率的提高相关。
Clin Exp Metastasis. 2009;26(7):663-71. doi: 10.1007/s10585-009-9265-8. Epub 2009 May 10.
8
Tumor-associated macrophages in clear cell renal cell carcinoma express both gastrin-releasing peptide and its receptor: a possible modulatory role of immune effectors cells.透明细胞肾细胞癌中的肿瘤相关巨噬细胞表达胃泌素释放肽及其受体：免疫效应细胞的可能调节作用。
World J Urol. 2010 Jun;28(3):335-41. doi: 10.1007/s00345-009-0492-z. Epub 2009 Dec 13.
9
Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy.肾细胞癌中C端胃泌素释放肽（GRP）衍生肽结合位点的鉴定：未来治疗的潜在靶点。
BJU Int. 2015 May;115(5):829-38. doi: 10.1111/bju.12886. Epub 2015 Jan 26.
10
Distribution of the pig gastrin-releasing peptide receptor and the effect of GRP on porcine Leydig cells.猪胃泌素释放肽受体的分布及 GRP 对猪睾丸间质细胞的作用。
Peptides. 2018 Jan;99:142-152. doi: 10.1016/j.peptides.2017.09.015. Epub 2017 Sep 28.
引用本文的文献
1
The development of peptide-boron difluoride formazanate conjugates as fluorescence imaging agents.肽-硼二氟甲臜缀合物作为荧光成像剂的研发
RSC Adv. 2020 May 19;10(32):18970-18977. doi: 10.1039/d0ra02104k. eCollection 2020 May 14.
2
In Vivo Biodistribution and Efficacy Evaluation of NeoB, a Radiotracer Targeted to GRPR, in Mice Bearing Gastrointestinal Stromal Tumor.靶向胃泌素释放肽受体（GRPR）的放射性示踪剂NeoB在携带胃肠道间质瘤小鼠体内的生物分布及疗效评估
Cancers (Basel). 2021 Mar 2;13(5):1051. doi: 10.3390/cancers13051051.
3
Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma.13 例犬胆囊神经内分泌癌的临床、组织病理学和免疫组织化学特征。
J Vet Diagn Invest. 2021 Mar;33(2):294-299. doi: 10.1177/1040638720978172. Epub 2020 Dec 2.
4
Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma.胃泌素释放肽受体靶向的纳米氧化石墨烯用于口腔鳞状细胞癌的近红外荧光成像。
Sci Rep. 2020 Jul 10;10(1):11434. doi: 10.1038/s41598-020-68203-y.
5
Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma.Trk抑制可减少尤因肉瘤中的细胞增殖，并增强化疗药物的效果。
Oncotarget. 2016 Jun 7;7(23):34860-80. doi: 10.18632/oncotarget.8992.
6
An exploratory study on 99mTc-RGD-BBN peptide scintimammography in the assessment of breast malignant lesions compared to 99mTc-3P4-RGD2.一项关于99mTc-RGD-BBN肽乳腺闪烁显像术与99mTc-3P4-RGD2相比在评估乳腺恶性病变中的探索性研究。
PLoS One. 2015 Apr 7;10(4):e0123401. doi: 10.1371/journal.pone.0123401. eCollection 2015.
7
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.胃泌素释放肽的表达可被人子宫平滑肌的长时间牵张所增加，其受体的拮抗剂可抑制收缩性。
J Physiol. 2012 May 1;590(9):2081-93. doi: 10.1113/jphysiol.2012.228239. Epub 2012 Mar 12.
8
Vaccines targeting the neovasculature of tumors.靶向肿瘤新生血管的疫苗。
Vasc Cell. 2011 Mar 8;3(1):7. doi: 10.1186/2045-824X-3-7.
9
Expression and ligand binding of bombesin receptors in pulmonary and intestinal carcinoids.在肺和肠类癌中脑肠肽受体的表达和配体结合。
J Endocrinol Invest. 2011 Oct;34(9):665-70. doi: 10.3275/7332. Epub 2010 Nov 8.
10
Tumor-associated macrophages in clear cell renal cell carcinoma express both gastrin-releasing peptide and its receptor: a possible modulatory role of immune effectors cells.透明细胞肾细胞癌中的肿瘤相关巨噬细胞表达胃泌素释放肽及其受体：免疫效应细胞的可能调节作用。
World J Urol. 2010 Jun;28(3):335-41. doi: 10.1007/s00345-009-0492-z. Epub 2009 Dec 13.
本文引用的文献
1
The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.血管生成受体激酶插入域受体（KDR）广泛分布于人体组织和肿瘤中，并在磷酸化后重新定位于细胞内。一项免疫组织化学研究。
Histopathology. 2003 Jul;43(1):33-9. doi: 10.1046/j.1365-2559.2003.01644.x.
2
Gastrin-releasing peptide is a growth factor for human neuroblastomas.胃泌素释放肽是人类神经母细胞瘤的一种生长因子。
Ann Surg. 2002 May;235(5):621-9; discussion 629-30. doi: 10.1097/00000658-200205000-00003.
3
Malignancy-associated allelic losses on the X-chromosome in foregut but not in midgut endocrine tumours.前肠而非中肠内分泌肿瘤中X染色体上与恶性肿瘤相关的等位基因缺失。
J Pathol. 2002 Apr;196(4):401-7. doi: 10.1002/path.1075.
4
Immunohistochemical prognostic indicators of gastrointestinal carcinoid tumours.胃肠道类癌肿瘤的免疫组化预后指标
Eur J Surg Oncol. 2002 Mar;28(2):140-6. doi: 10.1053/ejso.2001.1229.
5
Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorigenesis of midgut carcinoids.比较基因组杂交技术鉴定出18q22 - qter缺失是中肠类癌肿瘤发生过程中的一个早期特异性事件。
Am J Pathol. 2001 May;158(5):1803-8. doi: 10.1016/S0002-9440(10)64136-3.
6
The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter.人胃泌素释放肽受体基因结构、其组织表达及启动子
Gene. 2001 Feb 7;264(1):95-103. doi: 10.1016/s0378-1119(00)00596-5.
7
Neuroendocrine neoplasia. Current concepts.神经内分泌肿瘤。当前概念。
Am J Clin Pathol. 2000 Mar;113(3):331-5. doi: 10.1309/ETJ3-QBUK-13QD-J8FP.
8
Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa.蛙皮素家族受体和配体基因在人大肠癌及正常黏膜中的表达
Br J Cancer. 2000 Jan;82(1):124-30. doi: 10.1054/bjoc.1998.0888.
9
Characterization of gastrin-releasing peptide receptors aberrantly expressed by non-antral gastric adenocarcinomas.非胃窦部胃腺癌异常表达的胃泌素释放肽受体的特征分析
Peptides. 1999;20(2):229-37. doi: 10.1016/s0196-9781(98)00164-8.
10
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.阑尾经典型和杯状细胞类癌发病机制中的K-ras和p53突变
Cancer. 1999 Jul 1;86(1):14-21. doi: 10.1002/(sici)1097-0142(19990701)86:1<14::aid-cncr4>3.0.co;2-x.
Zotero 插件