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胃泌素释放肽受体靶向的纳米氧化石墨烯用于口腔鳞状细胞癌的近红外荧光成像。

Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma.

机构信息

Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.

Research Division/Biomolecular Imaging Center, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, 65201, USA.

出版信息

Sci Rep. 2020 Jul 10;10(1):11434. doi: 10.1038/s41598-020-68203-y.

DOI:10.1038/s41598-020-68203-y
PMID:32651409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7351765/
Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. Pathological biopsy is still the current gold standard for OSCC diagnosis; however, some drawbacks need to be overcome. Therefore, it is urgently needed to find a non-invasive targeted technology for OSCC early diagnosis. Fluorescent optical imaging using near infrared (NIR) dyes tagged to tumor specific target will benefit such developments. Gastrin releasing peptide receptor (GRPR) is an attractive target for OSCC imaging and therapy. In this study, we synthesized nano-graphene oxide (NGO) nanoparticles with GRPR-specific peptides AF750-6Ahx-Sta-BBN via hydrogen bond and π-π bonds (NGO-BBN-AF750), and investigated their receptor binding, cell uptake and internalization in HSC-3 cells. NGO-BBN-AF750 and AF750-6Ahx-Sta-BBN showed a similar binding affinity to GRPR on HSC-3 cells. In contrast to AF750-6Ahx-Sta-BBN antagonist peptide, NGO-BBN-AF750 showed cellular internalization property. Overall, this study proposes a NGO nanoclusters-based nanoprobe for GRPR targeted near-infrared fluorescence imaging for OSCC. Nanoparticle-based delivery systems have shown highly significant potential in the delivery of a wide range of therapeutic agents.

摘要

口腔鳞状细胞癌 (OSCC) 是发生在口腔黏膜的最常见恶性肿瘤。病理活检仍然是 OSCC 诊断的当前金标准；然而，需要克服一些缺点。因此，迫切需要找到一种用于 OSCC 早期诊断的非侵入性靶向技术。用肿瘤特异性靶标标记的近红外 (NIR) 染料进行荧光光学成像是有益的。胃泌素释放肽受体 (GRPR) 是 OSCC 成像和治疗的有吸引力的靶标。在这项研究中，我们通过氢键和π-π 键合成了具有 GRPR 特异性肽 AF750-6Ahx-Sta-BBN 的纳米氧化石墨烯 (NGO) 纳米颗粒 (NGO-BBN-AF750)，并研究了它们在 HSC-3 细胞中的受体结合、细胞摄取和内化。NGO-BBN-AF750 和 AF750-6Ahx-Sta-BBN 对 HSC-3 细胞上的 GRPR 表现出相似的结合亲和力。与 AF750-6Ahx-Sta-BBN 拮抗剂肽相反，NGO-BBN-AF750 表现出细胞内化特性。总体而言，本研究提出了一种基于 NGO 纳米团簇的用于 GRPR 靶向近红外荧光成像的纳米探针，用于 OSCC。基于纳米颗粒的递药系统在广泛的治疗剂的递送上显示出了非常显著的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/72c79eed00eb/41598_2020_68203_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/3db9003a2955/41598_2020_68203_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/249a48427634/41598_2020_68203_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/54d5a6c936ad/41598_2020_68203_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/fd80bd3ba48e/41598_2020_68203_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/d19042dfdd77/41598_2020_68203_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/eb34b82db5f1/41598_2020_68203_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/6cc7f7bfe0a1/41598_2020_68203_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/c9a9ae1a7196/41598_2020_68203_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/8f7598cbb095/41598_2020_68203_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/09733206c52d/41598_2020_68203_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/72c79eed00eb/41598_2020_68203_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/3db9003a2955/41598_2020_68203_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/249a48427634/41598_2020_68203_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/54d5a6c936ad/41598_2020_68203_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/fd80bd3ba48e/41598_2020_68203_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/d19042dfdd77/41598_2020_68203_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/eb34b82db5f1/41598_2020_68203_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/6cc7f7bfe0a1/41598_2020_68203_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/c9a9ae1a7196/41598_2020_68203_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/8f7598cbb095/41598_2020_68203_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/09733206c52d/41598_2020_68203_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/560f/7351765/72c79eed00eb/41598_2020_68203_Fig10_HTML.jpg

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