Neu Peter, Schlattmann Peter, Schilling Andreas, Hartmann Andreas
Department of Psychiatry, Charité-Hochschulmedizin Berlin, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
Psychosom Med. 2004 Jan-Feb;66(1):6-8. doi: 10.1097/01.psy.0000107880.03026.54.
There are a growing number of reports that depression may increase the risk of stroke. Little is known, however, about the pathophysiologic mechanisms underlying this association. Cerebrovascular reactivity (CVR) reflects the compensatory dilatory capacity of cerebral arterioles to a dilatory stimulus and is an important mechanism to provide constant cerebral blood flow. We hypothesized that CVR is reduced in patients with major depression, thus contributing to the association between depression and stroke.
We assessed CVR in 33 patients with unipolar depression and 26 healthy controls by calculating the increase in cerebral blood flow velocity after stimulation with acetazolamide. Blood flow velocities were measured by transcranial Doppler ultrasound.
Cerebrovascular reactivity was significantly reduced in depressed patients. Smoking was also associated with a significant reduction in CVR, whereas age and gender had no significant influence.
Cerebrovascular reactivity appears to be impaired in major depression. Further studies should clarify the mechanisms leading to this reduced CVR.
越来越多的报告表明抑郁症可能会增加中风风险。然而，对于这种关联背后的病理生理机制知之甚少。脑血管反应性（CVR）反映了脑小动脉对扩张刺激的代偿性扩张能力，是维持恒定脑血流量的重要机制。我们推测，重度抑郁症患者的CVR降低，从而导致了抑郁症与中风之间的关联。
我们通过计算乙酰唑胺刺激后脑血流速度的增加，评估了33例单相抑郁症患者和26名健康对照者的CVR。血流速度通过经颅多普勒超声测量。
抑郁症患者的脑血管反应性显著降低。吸烟也与CVR的显著降低有关，而年龄和性别则没有显著影响。
重度抑郁症患者的脑血管反应性似乎受损。进一步的研究应阐明导致CVR降低的机制。
