Jacob Ashok C, Zmuda Joseph M, Cauley Jane A, Metter E Jeffrey, Hurley Ben F, Ferrell Robert E, Roth Stephen M
Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, MD 20742, USA.
Eur J Hum Genet. 2004 May;12(5):372-6. doi: 10.1038/sj.ejhg.5201159.
Exogenous ciliary neurotrophic factor (CNTF) administration causes significant weight loss in both humans and animal models, but the effects of endogenous CNTF and the CNTF null allele on body composition are not fully understood. A recent study in a European cohort demonstrated a significantly higher body weight and body mass index (BMI) in older males homozygous for the CNTF null allele (A/A genotype). We sought to replicate these findings in three cohorts: the Baltimore Longitudinal Study on Aging (BLSA) consisting of 422 adult men and women (19-90 years); the Study of Osteoporotic Risk in Men (STORM) consisting of 333 older men (50-84 years); and a third sample obtained by combining older males aged 59-73 years from the BLSA and STORM cohorts (n=286). In contrast to the European study, we were unable to detect a significant association between CNTF genotype and body weight in the BLSA (P=0.49), the STORM (P=0.28), or the combined samples (P=0.72). There was also no significant association observed between CNTF genotype and BMI in the BLSA (P=0.59), the STORM (P=0.34) or the combined (P=0.56) samples. In addition, we were unable to detect a significant association between CNTF genotype and total body fat (P=0.95) or fat-free mass (P=0.86) in the BLSA cohort. Our results do not support an effect of the CNTF null allele on body composition, contrary to previous findings.
外源性睫状神经营养因子（CNTF）给药可导致人类和动物模型出现显著体重减轻，但内源性CNTF及CNTF无效等位基因对身体组成的影响尚未完全明确。最近一项针对欧洲队列的研究表明，携带CNTF无效等位基因纯合子（A/A基因型）的老年男性体重和体重指数（BMI）显著更高。我们试图在三个队列中重复这些发现：巴尔的摩老龄化纵向研究（BLSA），包括422名成年男性和女性（19 - 90岁）；男性骨质疏松风险研究（STORM），包括333名老年男性（50 - 84岁）；以及通过合并BLSA和STORM队列中59 - 73岁的老年男性获得的第三个样本（n = 286）。与欧洲的研究相反，我们在BLSA队列（P = 0.49）、STORM队列（P = 0.28）或合并样本（P = 0.72）中均未检测到CNTF基因型与体重之间存在显著关联。在BLSA队列（P = 0.59）、STORM队列（P = 0.34）或合并样本（P = 0.56）中，CNTF基因型与BMI之间也未观察到显著关联。此外，在BLSA队列中，我们也未检测到CNTF基因型与全身脂肪（P = 0.95）或去脂体重（P = 0.86）之间存在显著关联。与之前的研究结果相反，我们的研究结果不支持CNTF无效等位基因对身体组成有影响。
