Kuzuya M, Ando F, Iguchi A, Shimokata H
Department of Geriatrics, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
Int J Obes (Lond). 2006 Nov;30(11):1609-14. doi: 10.1038/sj.ijo.0803296. Epub 2006 Jul 25.
To investigate whether Leu72Met polymorphism of the preproghrelin gene is associated with overweight/obesity in middle-aged and older Japanese.
Cross-sectional analysis.
A total of 2238 community-dwelling middle-aged and older Japanese people (age: 40-79 years) who participated in the first wave of examinations in the National Institute for Longevity Sciences - Longitudinal Study of Aging from April 1998 to March 2000.
The Leu72Met polymorphism of prepoghrelin gene, anthropometric variables including body weight, body mass index (BMI), waist circumference, waist-to-hip ratio and whole-fat mass and biochemical variables including serum lipid levels, fasting plasma glucose, insulin and homeostasis model assessment for insulin resistance.
The frequencies of the Leu72Leu, Leu72Met and Met72Met alleles were 63.4, 32.7 and 4.0%, respectively. No differences in the genotype distributions of the Leu72Met polymorphism were found between genders or age groups, and no significant associations were observed between polymorphism and anthropometric variables in women and older men. However, middle-aged men who were 72Met allele carriers showed a higher body weight change from body weight at 18 years of age, as well as a higher waist circumference and a tendency to a higher waist-hip-ratio than noncarriers. Although there were no significant differences in the genotype distribution according to BMI in women and older men, a significantly higher frequency of the 72Met allele was found in the higher BMI group (BMI> or =25 kg/m(2)) of middle-aged men than in the normal-weight group. No significant associations were observed between polymorphism and serum lipid, glucose or insulin levels.
These results suggest that the 72Met allele of the preproghrelin gene is a contributing factor for midlife weight change in men.
研究前胃促生长素原基因Leu72Met多态性是否与日本中老年人群的超重/肥胖相关。
横断面分析。
共有2238名居住在社区的日本中老年人（年龄：40 - 79岁），他们于1998年4月至2000年3月参加了国立长寿科学研究所 - 衰老纵向研究的第一轮检查。
前胃促生长素原基因的Leu72Met多态性、人体测量变量（包括体重、体重指数（BMI）、腰围、腰臀比和全身脂肪量）以及生化变量（包括血脂水平、空腹血糖、胰岛素和胰岛素抵抗的稳态模型评估）。
Leu72Leu、Leu72Met和Met72Met等位基因的频率分别为63.4%、32.7%和4.0%。在性别或年龄组之间未发现Leu72Met多态性的基因型分布存在差异，并且在女性和老年男性中未观察到多态性与人体测量变量之间存在显著关联。然而，携带72Met等位基因的中年男性与非携带者相比，18岁时体重变化更高，腰围更高，腰臀比也有升高趋势。虽然在女性和老年男性中，根据BMI的基因型分布没有显著差异，但在中年男性的高BMI组（BMI≥25 kg/m²）中，72Met等位基因的频率显著高于正常体重组。未观察到多态性与血脂、血糖或胰岛素水平之间存在显著关联。
这些结果表明，前胃促生长素原基因的72Met等位基因是男性中年体重变化的一个影响因素。
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