Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues.
作者信息
Miles Steven M, Leatherbarrow Robin J, Marsden Stephen P, Coates William J
机构信息
Department of Chemistry, Imperial College London, South Kensington Campus, London, UKSW7 2AZ.
出版信息
Org Biomol Chem. 2004 Feb 7;2(3):281-3. doi: 10.1039/b312908j. Epub 2003 Dec 24.
DOI:10.1039/b312908j
PMID:14747852
Abstract
Bowman-Birk inhibitor analogues containing 2, 3 and 4-carbon analogues of the natural disulfide were synthesised via solid phase microwave-assisted RCM and found to have K(i) values against chymotrypsin in the low to sub-micromolar range, the best replacement for the disulfide arising from the linkage by RCM of two l-homoallylglycine residues.
摘要
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