欧洲各急性精神科病房精神药物处方模式的比较。
Comparisons of psychotropic drug prescribing patterns in acute psychiatric wards across Europe.
作者信息
Bowers Len, Callaghan Patrick, Clark Nicola, Evers Catharine
机构信息
Department of Mental Health and Learning Disability, City University London, Philpot Street, London E1 2EA, UK.
出版信息
Eur J Clin Pharmacol. 2004 Mar;60(1):29-35. doi: 10.1007/s00228-003-0719-7. Epub 2004 Jan 28.
OBJECTIVE
To compare prescribed daily doses (PDDs) of psychotropic drugs in several European centres.
METHOD
A one-day census of psychotropic drug prescriptions to 613 patients in 39 acute psychiatric wards in ten countries.
RESULTS
Patients in Spain were on most drugs; patients in Germany were on the fewest. Chlorpromazine equivalents in Denmark, England, Germany and Spain were at high levels as were diazepam equivalents in Belgium, Finland, The Netherlands and Norway. Newer anti-psychotics were used in the majority of centres, although older anti-psychotics were used commonly in three centres.
CONCLUSION
The high doses of psychotropic drugs patients receive in some centres may be having little additional therapeutic effect and could increase their risk of side effects. The use of older anti-psychotics in some centres may be causing side effects that could be reduced by using newer anti-psychotics.
目的
比较欧洲多个中心的精神药物规定日剂量（PDDs）。
方法
对十个国家39个急性精神科病房的613名患者的精神药物处方进行为期一天的普查。
结果
西班牙的患者使用的药物最多；德国的患者使用的药物最少。丹麦、英国、德国和西班牙的氯丙嗪等效剂量处于较高水平，比利时、芬兰、荷兰和挪威的地西泮等效剂量也较高。大多数中心使用了新型抗精神病药物，不过有三个中心仍普遍使用较老的抗精神病药物。
结论
一些中心的患者接受的高剂量精神药物可能几乎没有额外的治疗效果，还可能增加副作用风险。一些中心使用较老的抗精神病药物可能会导致副作用，而使用新型抗精神病药物可能会减少这些副作用。
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