Payne Anthony Michael, Delbono Osvaldo
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Exerc Sport Sci Rev. 2004 Jan;32(1):36-40. doi: 10.1097/00003677-200401000-00008.
Excitation-contraction (EC) uncoupling is a major cause of decreased muscle force generating capacity (specific force). However, the underlying mechanisms of EC uncoupling in muscle from aging mammals have not been characterized. We propose that impaired motor neuron function with aging leading to muscle denervation, a process probably initiated earlier than detected by in vitro morphologic techniques, results in EC uncoupling.
兴奋-收缩（EC）解偶联是肌肉力量产生能力（比力）下降的主要原因。然而，衰老哺乳动物肌肉中EC解偶联的潜在机制尚未明确。我们提出，随着年龄增长，运动神经元功能受损导致肌肉去神经支配，这一过程可能比体外形态学技术检测到的更早开始，从而导致EC解偶联。
