黄素酶活性的模型系统：辅因子氧化还原调节中氢键和芳香堆积的相互作用。
Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation.
作者信息
Gray Mark, Goodman Allan J, Carroll Joseph B, Bardon Kevin, Markey Michael, Cooke Graeme, Rotello Vincent M
机构信息
Department of Chemistry, University of Massachusetts, Amherst 01003, USA.
出版信息
Org Lett. 2004 Feb 5;6(3):385-8. doi: 10.1021/ol036279g.
PMID:14748599
Abstract
[structure: see text] A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and pi-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.
摘要
[结构：见正文] 已开发出一种模型系统，用于研究黄素衍生物结合过程中芳香堆积与氢键之间的协同作用。结果表明，氢键和π-堆积单元的特性在很大程度上决定了受体对氧化态和自由基阴离子态黄素的整体亲和力。
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