• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

黄素酶活性的模型系统：辅因子氧化还原调节中氢键和芳香堆积的相互作用。

Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation.

作者信息

Gray Mark, Goodman Allan J, Carroll Joseph B, Bardon Kevin, Markey Michael, Cooke Graeme, Rotello Vincent M

机构信息

Department of Chemistry, University of Massachusetts, Amherst 01003, USA.

出版信息

Org Lett. 2004 Feb 5;6(3):385-8. doi: 10.1021/ol036279g.

DOI:10.1021/ol036279g
PMID:14748599
Abstract

[structure: see text] A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and pi-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.

摘要

[结构：见正文] 已开发出一种模型系统，用于研究黄素衍生物结合过程中芳香堆积与氢键之间的协同作用。结果表明，氢键和π-堆积单元的特性在很大程度上决定了受体对氧化态和自由基阴离子态黄素的整体亲和力。

相似文献

1
Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox modulation.黄素酶活性的模型系统：辅因子氧化还原调节中氢键和芳香堆积的相互作用。
Org Lett. 2004 Feb 5;6(3):385-8. doi: 10.1021/ol036279g.
2
Flavoenzyme structure and function. Approaches using flavin analogues.黄素酶的结构与功能。使用黄素类似物的方法。
Methods Mol Biol. 1999;131:157-79. doi: 10.1385/1-59259-266-X:157.
3
Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs.黄素腺嘌呤二核苷酸（FAD）和黄素单核苷酸（FMN）与酶的共价连接：现状
Protein Sci. 1998 Jan;7(1):7-20. doi: 10.1002/pro.5560070102.
4
Potentiometric and further kinetic characterization of the flavin-binding domain of Saccharomyces cerevisiae flavocytochrome b2. Inhibition by anions binding in the active site.酿酒酵母黄素细胞色素b2黄素结合结构域的电位测定及进一步的动力学表征。活性位点中阴离子结合的抑制作用。
Biochemistry. 2007 Apr 17;46(15):4661-70. doi: 10.1021/bi602634y. Epub 2007 Mar 21.
5
Role of adenine in thymine-dimer repair by reduced flavin-adenine dinucleotide.腺嘌呤在黄素腺嘌呤二核苷酸还原物修复胸腺嘧啶二聚体中的作用。
J Phys Chem B. 2008 Aug 28;112(34):10758-64. doi: 10.1021/jp804506t. Epub 2008 Aug 6.
6
Model systems for flavoenzyme activity: recognition and redox modulation of flavin mononucleotide in water using nanoparticles.黄素酶活性的模型系统：利用纳米颗粒在水中对黄素单核苷酸的识别与氧化还原调节
Chem Commun (Camb). 2006 Oct 14(38):4033-5. doi: 10.1039/b608928c. Epub 2006 Aug 21.
7
Effect of the Insertion of a Glycine Residue into the Loop Spanning Residues 536-541 on the Semiquinone State and Redox Properties of the Flavin Mononucleotide-Binding Domain of Flavocytochrome P450BM-3 from Bacillus megaterium.在巨大芽孢杆菌黄素细胞色素P450BM-3的黄素单核苷酸结合结构域中，于跨越536 - 541位残基的环中插入甘氨酸残基对半醌状态和氧化还原性质的影响
Biochemistry. 2008 Dec 30;47(52):13788-99. doi: 10.1021/bi800954h.
8
Mechanism-based inhibitors of cytokinin oxidase/dehydrogenase attack FAD cofactor.基于机制的细胞分裂素氧化酶/脱氢酶抑制剂攻击黄素腺嘌呤二核苷酸（FAD）辅因子。
J Mol Biol. 2008 Jul 25;380(5):886-99. doi: 10.1016/j.jmb.2008.05.044. Epub 2008 May 24.
9
The role of adenine in fast excited-state deactivation of FAD: a femtosecond mid-IR transient absorption study.腺嘌呤在黄素腺嘌呤二核苷酸快速激发态失活中的作用：飞秒中红外瞬态吸收研究
J Phys Chem B. 2009 Jul 9;113(27):9059-61. doi: 10.1021/jp905020u.
10
Modulation of the redox properties of the flavin cofactor through hydrogen-bonding interactions with the N(5) atom: role of alphaSer254 in the electron-transfer flavoprotein from the methylotrophic bacterium W3A1.通过与N(5)原子的氢键相互作用调节黄素辅因子的氧化还原性质：αSer254在甲基营养型细菌W3A1的电子传递黄素蛋白中的作用。
Biochemistry. 2007 Mar 6;46(9):2289-97. doi: 10.1021/bi0616293. Epub 2007 Feb 10.

引用本文的文献

1
Spectroscopic Characterization of the Photolysis of Riboflavin (Vitamin B2) via Time-Resolved Mass Spectrometry and IRMPD Spectroscopy.通过时间分辨质谱和红外多光子解离光谱对核黄素（维生素B2）光解的光谱表征
J Phys Chem A. 2025 Jun 12;129(23):5082-5091. doi: 10.1021/acs.jpca.5c02175. Epub 2025 May 29.
2
π-π stacking interactions in tryptophan-lumiflavin-tyrosine: a structural model for riboflavin insertion into riboflavin-binding protein.色氨酸-黄素单核苷酸-酪氨酸中的π-π堆积相互作用：黄素单核苷酸插入黄素结合蛋白的结构模型
J Mol Model. 2025 Jan 8;31(2):38. doi: 10.1007/s00894-024-06233-3.
3
The redox potential of flavin derivatives as a mediator in biosensors.
黄素衍生物作为生物传感器中的介体的氧化还原电位。
J Mol Model. 2021 Feb 28;27(3):96. doi: 10.1007/s00894-020-04650-8.
4
Theoretical investigation into the cooperativity effect between the intermolecular π∙π and H-bonding interactions in the curcumin∙cytosine∙HO system.姜黄素∙胞嘧啶∙HO体系中分子间π∙∙π和氢键相互作用协同效应的理论研究
J Mol Model. 2018 Sep 28;24(10):298. doi: 10.1007/s00894-018-3836-z.
5
Probing substituent effects in aryl-aryl interactions using stereoselective Diels-Alder cycloadditions.利用立体选择性狄尔斯-阿尔德环加成反应探究芳基-芳基相互作用中的取代基效应。
J Am Chem Soc. 2010 Mar 17;132(10):3304-11. doi: 10.1021/ja903653j.